Abstract. Invasive breast carcinoma of no special type (IBC-NST) with medullary pattern is an uncommon histologic type of invasive breast carcinoma. It is associated with high-grade, poorly differentiated tumor cells that form large sheets of irregular confluent tumor cells associated with a prominent lymphocytic infiltrate. Invasive carcinoma of no special type (IC-NST) is known to be one of the most prevalent kinds of breast cancer, hence the growing research interest in studying automated systems that can detect the presence of breast tumors and appropriately classify them into subtypes. Machine learning (ML) and, more specifically, deep learning (DL) techniques have been used to approach this problem. However Background Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico-pathological heterogeneity and prognostic significance of TNBC histologic variants, comparing “special types” to high-grade invasive breast carcinomas of no special type “No Special Type” (“NST”) Microinvasive Carcinoma Invasive breast carcinoma ≤1mm in size Usually adjacent to an areas of DCIS, often high-grade. Earliest recognizable form of invasive carcinoma • Invasion beyond myoepithelium • Small, angulated clusters of tumor cells infiltrating stroma • Often desmoplastic stromal changes Dari hasil pemeriksaan yang Anda sampaikan didapatkan hasil invasive breast carcinoma NST grade 3. Hasil inimenunjukkan suatu kanker payudara yang disebut juga dengan invasive ductal carcinoma.Grade 3 menunjukkangambaran yang berbeda terhadap perubahan mutasi sel, inti sel di bawah mikroskop yang sudah high grade atau poorly differentiated. Diffuse invasive breast carcinomas are rare tumors associated with unfavorable prognostic parameters. This growth pattern is often related to invasive lobular cancer (ILC). Diffuse ductal breast carcinoma of no special type (NST) is largely under-recognized in the literature. We identified 70 diffuse invasive breast carcinomas in a consecutive series of 1249 invasive tumors. Based on Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and β-catenin staining) features. Moreover, ILC displays a poor response to neoadjuvant therapy, a different metastatic pattern compared to invasive breast carcinoma of no special type Invasive Ductal Carcinoma of Breast (NOS) is a very common type of breast cancer. Almost 70-80% of breast cancers are Ductal Carcinoma NOS types. Middle-aged and older women past the age of 40 years are affected, though women over 65 years have the highest risk. Although both women and men are capable of developing the condition, it is much IBC of no special type (NST) was formerly named invasive ductal carcinoma due to its resemblance to breast ductules in varying forms and is still recommended to be termed invasive ductal carcinoma not otherwise specified by some authors. It comprises a wide spectrum of morphologies that do not display features of any special morphological 1 INTRODUCTION. Invasive breast carcinoma of no special type with medullary pattern (BCNST-MP) is a rare breast tumor that accounts for <5% of all invasive breast carcinomas. 1 Diagnosis of this tumor usually is defined by histologic diagnostic criteria as proposed by Ridolfi et al. 2 Morphologically, this tumor displays dense lympho-plasmacytic infiltration, pushing borders, cells with high Kimk.